STUDIES & RESEARCH
Our goal is to compile and provide the most essential and up-to-date information on Acanthamoeba Keratitis through a user-friendly platform. This includes articles, case studies, publications, research, clinical trials, and tutorials related to AK.
For healthcare professionals, we segment the information into 3 categories:
1.- Diagnosis and Treatment
2.- Advanced Techniques
3.- Epidemiology
If you have any inquiries or valuable information to share, feel free to contact us.
Diagnosis and Treatment
- Global Alliance againts Acanthamoeba Keratitis White Paper. A collaboration of diverse stakeholders that include patients, clinicians, researchers, industry and regulators passionate about preventing this rare but serious disease and improving the outcomes for patients.– AK Eye Foundation Oct- (2024)
- The Orphan Drug for Acanthamoeba Keratitis (ODAK) Trial: PHMB 0.08% (Polihexanide) and Placebo versus PHMB 0.02% and Propamidine 0.1% John K G Dart et al – Ophtalmology – (2024)
- Case Study: 54 year old man with acute painful redness in his right eye with photophobia after he slept in his contact lens the previous night. Zachary Reynard, Taher Eleiwa – Eye Meds Now – (2024)
- Assessing PCR-Positive Acanthamoeba keratitis—A Retrospective Chart Review. This study raises awareness of patient education in contact lens handling and screens for further microbial co-infections in suspected Acanthamoeba cases. – Microorganisms – (2024)
- Acanthamoeba epitheliopathy: Importance of early diagnosis. Gavin Li et Al. American Journal of Ophthalmology Case Reports (2022)
- Diagnosing and monitoring the characteristics of Acanthamoeba keratitis using slit scanning and laser scanning in vivo confocal microscopy. K. Curro-Tafili et al – OPO – (2022)
- Acanthamoeba keratitis, Pathology, Diagnosis and Treatment. Fanselow N, et al. Pathogens (2021)
- An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment. Jacob Lorenzo-Morales et al. NCBI (2015)
- The rising tide of Acanthamoeba keratitis in Auckland, New Zealand: a 7‐year review of presentation, diagnosis and outcomes. James McKelvie Franzco et al. FRANZCO DSc (2009–2016)
- Challenges in Acanthamoeba Keratitis: A Review. Giuseppe Varacalli et al., J. Clin. Med. 2021, 10(5), 942; – MDPI (2021)
- Outcomes of amoebic, fungal, and bacterial keratitis: A retrospective cohort study. Moe CA et al. – PLOS ONE 17 – (2022)
- Acanthamoeba Keratitis: A Single-Institution Series of Four Cases With Literature Review. Clarissa Smith et al – Cureus – (2022)
- Confocal microscopy in the diagnosis of acanthamoeba keratitis. Kasparova EA et al. – PMID – (2021)
- Ocular Hypertension, Glaucoma Frequent Complications of Acanthamoeba Keratitis Carlene Majorino – Optometry Advisor – (2021)
Advanced Techniques
- Same‑session dual chromophore riboflavin/ UV‑A and rose bengal/green light PACK‑CXL in Acanthamoeba keratitis: a case report. Hafezi et al. Eye and Vision 12:2 (2025)
- The Orphan Drug for Acanthamoeba Keratitis (ODAK) Trial: PHMB 0.08% (Polihexanide) and Placebo versus PHMB 0.02% and Propamidine 0.1% John K G Dart et al – Ophtalmology – (2024)
- Novel Map Biopsy Technique to Define the Extent of Infection Before Penetrating Keratoplasty for Acanthamoeba Keratitis. Simpson, Alasdair et al – Cornea – (2023)
- Ultrasensitive and rapid diagnostic tool for detection of Acanthamoeba castellanii. Susanna Haapanen et al – Science Direct (2023)
- The role of the calcofluor white staining in the diagnosis of Acanthamoeba keratitis. Elhardt, C. et al. J Ophthal Inflamm Infect 13, 23 (2023)
- Therapeutic Corneal Transplantation in Acanthamoeba Keratitis: Penetrating Versus Lamellar Keratoplasty. Di Zazzo, Antonio MD et al– Cornea– (2022)
- Voriconazole in the successful management of a case of Acanthamoeba-Cladosporium keratitis. Anita Raghavan et al – American Journal of Ophthalmology Case Reports – (2021)
- Systemic Miltefosine as an Adjunct Treatment of Progressive Acanthamoeba Keratitis. Andrea Naranjo et al – PubMed – (2021)
- Accelerated collagen cross-linking in the management of advanced Acanthamoeba keratitis. Cartes Cristian et al – Scielo – (2019)
- Riboflavin and Ultraviolet Light A Therapy as an Adjuvant Treatment for Medically Refractive Acanthamoeba Keratitis. Yasin A. Khan et al – kalyanieye – (2011)
- Early Deep Anterior Lamellar Keratoplasty (DALK) for Acanthamoeba Keratitis Poorly Responsive to Medical Treatment. Sarnicola, Enrica MD et al – Cornea – (2016)
Epidemiology
- Understanding Acanthamoeba Keratitis: An In-Depth Review of a Sight-Threatening Eye Infection. Francesco Petrillo et al. – Microorganisms – (2024)
- Perspectives on the incidence of Acanthamoeba Keratitis: A Systematic Review and Meta-Analysis. Francesco Aiello et al. – Ophtalmology – (2024)
- The global epidemiology and clinical diagnosis of Acanthamoeba keratitis. Yuheng Zhang et al.– Science Direct – (2023)
- Acanthamoeba spp. aggregate and encyst on contact lens material increasing resistance to disinfection. Campolo Allison et al – Microbiology – Volume 13 – (2022)
- Acanthamoeba keratitis: an increasingly common infectious disease of the cornea. Binod Rayamajhee et al. – The Lancet Microbe – (2021)
- Acanthamoeba spp. as agents of disease in humans. Marciano-Cabral F et al. Clin Microbiol Rev. (2003)
- The rising incidence of Acanthamoeba keratitis: A 7-year nationwide survey and clinical assessment of risk factors and functional outcomes. Anna C Randag et al. – Plos One – (2019)
- Acanthamoeba keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications. Nicole Carnt et al – Br J Ophthalmol – (2018)